Medications That Increase Dry Mouth — and What You Can Do About It

Medications That Increase Dry Mouth — and What You Can Do About It

Dry mouth (xerostomia) is one of the most overlooked side effects of modern medications — and today, one category is creating a massive wave of complaints:

GLP-1 Weight Loss Drugs (Ozempic, Wegovy, Mounjaro, Zepbound)

These medications have helped millions lose weight and improve metabolic health. But for many users, an unexpected issue shows up fast:

A constant dry mouth feeling — sticky, pasty, uncomfortable, and distracting.

If you’re experiencing this, here’s why it’s happening and how to manage it effectively.


Why GLP-1 Medications Cause Dry Mouth

GLP-1s include:

  • Semaglutide: Ozempic, Wegovy, Rybelsus

  • Tirzepatide: Mounjaro, Zepbound

  • Liraglutide: Saxenda

  • Dulaglutide: Trulicity

These medications influence multiple systems:

  • Reduced appetite → less chewing → less saliva

  • Hormonal changes that impact the salivary glands

  • Altered digestion that affects hydration

  • Lower overall fluid intake because you feel less thirsty

For many users, dry mouth begins within a few doses.


Other Medications That Commonly Cause Dry Mouth

1. Anxiety & Depression Medications

SSRIs, SNRIs, TCAs (Zoloft, Lexapro, Prozac, Cymbalta)

2. Blood Pressure Medications

Lisinopril, Metoprolol, Atenolol, Hydrochlorothiazide

3. Antihistamines & Allergy Meds

Benadryl, Zyrtec, Claritin

4. Pain Medications

Opioids, Tramadol, Hydrocodone

5. Urinary Incontinence Medications

Oxybutynin, Tolterodine

6. Asthma & COPD Inhalers

Albuterol, Spiriva, Advair


Why Dry Mouth Matters

Saliva plays a vital role. Without enough of it, your mouth becomes more vulnerable to:

  • Cavities

  • Gum irritation

  • Mouth sores

  • Bad breath

  • Difficulty tasting

  • Trouble speaking

Dry mouth is more than a nuisance — it affects total oral health.


OPS Dry Mouth Pouches: The Most Effective Relief for GLP-1 Dry Mouth

GLP-1 users often find that:

  • Sprays don’t last

  • Lozenges dissolve too fast

  • Gum triggers nausea

  • Water doesn’t actually hydrate the mouth

OPS Dry Mouth Pouches solve all of these issues at once.

Why OPS is the best solution for GLP-1 medication users:

  • Slow-release hydration that lasts far longer than sprays or lozenges

  • Hyaluronic acid binds to oral tissues to restore moisture

  • Xylitol supports natural saliva flow

  • ✔ No chewing or sucking — ideal for sensitive stomachs

  • ✔ Clean, gentle ingredients

  • ✔ Discreet and hands-free for use anywhere

Place a pouch between your gum & cheek, and it delivers steady, comfortable hydration.


Additional Ways to Manage Dry Mouth

1. Increase daily water intake

Sip regularly, even without feeling thirsty.

2. Avoid alcohol-based mouthwashes

They worsen dryness.

3. Reduce caffeine and alcohol

Both decrease saliva production.

4. Choose sugar-free oral products

You’re more cavity-prone when saliva is low.

5. Chew sugar-free gum (if tolerated)

Some GLP-1 users experience nausea with chewing, so use only if comfortable.


Speak With Your Doctor If Dry Mouth Becomes Severe

You may benefit from adjustments such as:

  • Different dosing

  • Alternative medication

  • Adding oral-care support

Never hesitate to bring it up — dry mouth is a legitimate side effect.


Final Thoughts

GLP-1 medications have incredible benefits, but dry mouth is becoming a widespread and frustrating side effect. Thankfully, you can manage it easily and effectively.

OPS Dry Mouth Pouches provide long-lasting, comfortable hydration designed specifically for persistent dry mouth caused by medications like Ozempic, Wegovy, Mounjaro, and Zepbound.

They’re simple, discreet, effective — and one of the easiest ways to keep your mouth comfortable and healthy.

Back to blog